The Putin Protein and its Role in Invasive Russocarcinoma

The protein “putin” normally acts to regulate the flow of methane through the digestive system. However, a nonsense mutation of the corresponding KGB gene results in an antimorphic protein, “RASputin” which is linked to a highly invasive cancer known as russocarcinoma.

Towards a Total Synthesis of 3,8-Unethoxy-Discombobulne and Discovery of the Furzmeister-Wencke Reagent

3,8-unethoxy-discombobulannulene is a wtfwereyouthin-kingolide-type natural product which was recently isolated from a mould found growing on a cheese omelette in Kent (Fig. 1).