The natural product thiotimoline was isolated from the bark of Rosaceae Karlsbadensis rufo and its structure was unambiguously determined by time-resolved X-ray crystallomancy and spectroscopy. A total synthesis of thiotimoline was conducted following a convergent strategy. The pivotal transformations in this synthesis were a tandem Suzuki-Miyaura/Schinkenfaust radical cross-spifflication, a Szymankowszczyzna allylic inquisition and a [3+2+3+2] Puccini-Gershwin echocyclisation in A♭ major. An unnatural isomer of thiotimoline was also synthesised, and a theory of kairality and chronomers is presented and discussed.
Tag Archives: Chemistry
Frank Furious and the Very Cross Coupling: A Pre-Emptive Eulogy
Synthesis and Characterization of a Novel Nitrotoluene Polymer: TNTP
We report the first synthesis of poly(TNT), and an appraisal of its properties and commercial potential.
On the Bending of SPOONS
Quantum mechanical calculations were performed on SPOONS that show that there is not an inherent tendency for SPOONS to bend.
Supernatural Products: An Illiterature Review
Supernatural products are just like any other molecules, only more so. This illiterature review presents a recap of supernatural products with structures that have been elucidated or reassigned in the last decade(ish).
No more flux to give: six things to do with a decommissioned NMR
How to repurpose an old instrument.
Four People Hospitalised After Chemical Warfare Agent Found in Scented Candles
A simple mistake of chemical nomenclature has resulted in tragedy this week.
Novel Treatment of Electrile Dysfunction and Rigor Moietis with Energy Transfer Catalysis
What to do when molecules go floppy.
Can you explain your grad school research to relatives over Thanksgiving Dinner?
You are going home for Thanksgiving and your family wants you to explain what you’re studying through this Choose Your Own Adventure
Biscuits that Burst in the Mouth: Chocolate-and Sodium-Chip Cookies
A recipe for the cookies with latest superfood: sodium metal.