Toward Slower, Less Accurate, More Expensive, and Worse Density Functional Theory: A Natural-Stupidity-Assisted Method for Quantum Simulation

In this work, we present Natural Stupidity (NS) as a pioneering anti-optimization framework for Density Functional Theory (DFT) calculations.

Progress Towards the Total Synthesis of Labyrinthamine

We, the chemists of Twitter, here set forth our syntheses, that time may not decompose what our hands have brought into being. We report great and wonderful deeds, manifested by both theoretical and experimental chemists, and together with all this, we discuss the reasons why we sought to make labyrinthamine.

You Twist Me Right Round Baby: The Total Synthesis of Mobiustrine A

We report the total synthesis of the supernatural product mobiustrine A, starting from isoheptane. The key steps in our synthesis were a [2+2]+[2+2] cycloaddition, a Bonnie-Clyde cross-conjugal visitation, an enzymatic epoxide unzipping, and a Morbin rearrangement.