The natural product thiotimoline was isolated from the bark of Rosaceae Karlsbadensis rufo and its structure was unambiguously determined by time-resolved X-ray crystallomancy and spectroscopy. A total synthesis of thiotimoline was conducted following a convergent strategy. The pivotal transformations in this synthesis were a tandem Suzuki-Miyaura/Schinkenfaust radical cross-spifflication, a Szymankowszczyzna allylic inquisition and a [3+2+3+2] Puccini-Gershwin echocyclisation in A♭ major. An unnatural isomer of thiotimoline was also synthesised, and a theory of kairality and chronomers is presented and discussed.
Author Archives: Günther Schlonk
Capra stabilis: The Mythical Mountain Goat with Uneven Legs
This literature review summarises the current body of knowledge concerning Capra stabilis, the even-toed ungulate commonly known as the dahu.
Frank Furious and the Very Cross Coupling: A Pre-Emptive Eulogy
Synthesis and Characterization of a Novel Nitrotoluene Polymer: TNTP
We report the first synthesis of poly(TNT), and an appraisal of its properties and commercial potential.
On the Bending of SPOONS
Quantum mechanical calculations were performed on SPOONS that show that there is not an inherent tendency for SPOONS to bend.
EluciDATE: Matchmaking for Scientists
We report the development of a dedicated networking platform to facilitate professional and romantic matchmaking for scientists.
Supernatural Products: An Illiterature Review
Supernatural products are just like any other molecules, only more so. This illiterature review presents a recap of supernatural products with structures that have been elucidated or reassigned in the last decade(ish).
No more flux to give: six things to do with a decommissioned NMR
How to repurpose an old instrument.
Using Quartz Crystal Macrobalance to Predict Undergraduate Grades
G. Acidic-Puree1 and J. Mann2 Abstract: We are fucking over undergrads so we’ve got more time to drink expensive beer. 1. Introduction Marking exam papers is hard work. Especially when one’s boss insists on a failure rate of no less than 70 %, because “only the hard may enter the garden” (old German saying, translated).Continue reading “Using Quartz Crystal Macrobalance to Predict Undergraduate Grades”
Four People Hospitalised After Chemical Warfare Agent Found in Scented Candles
A simple mistake of chemical nomenclature has resulted in tragedy this week.